Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5

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Dust particlesinduced intracellular Ca signaling and reactive oxygen species in lung fibroblast cell line MRC5

Author contributions: D.U.L. and S.Y.K. performed cell-based assay experiments. D.U.L. and M.J.J. performed Ca measurement. J.Y.K. performed the statistical analysis. J.H.H. supervised and coordinated the study. J.H.H. and J.Y.K. wrote the manuscript. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted...

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Mitochondrial reactive oxygen species and Ca2+ signaling.

Mitochondria are an important source of reactive oxygen species (ROS) formed as a side product of oxidative phosphorylation. The main sites of oxidant production are complex I and complex III, where electrons flowing from reduced substrates are occasionally transferred to oxygen to form superoxide anion and derived products. These highly reactive compounds have a well-known role in pathological...

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Reactive oxygen species and cell signaling with lung ischemia.

In summary, our studies, utilizing the intact lung and several in vitro models, have shown a characteristic response of flow-adapted endothelial cells to ischemia. We believe that this effect represents a response to decreased shear stress since it is unrelated to cellular oxygenation. The response is characterized by endothelial cell depolarization, followed by activation of the membrane-bound...

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Reactive oxygen species and cell signaling.

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA may ensue. Such a state of "oxidative stress" is thought to contribute to the pathogenesis of a number of human diseases including those of the lun...

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Reactive oxygen species in cell signaling

Thannickal, Victor J., and Barry L. Fanburg. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279: L1005–L1028, 2000.—Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA ...

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ژورنال

عنوان ژورنال: The Korean Journal of Physiology & Pharmacology

سال: 2017

ISSN: 1226-4512,2093-3827

DOI: 10.4196/kjpp.2017.21.3.327